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Semaglutide: What Side Effects Can I Expect?

Updated: Jan 18, 2023

Semaglutide is a prescription medication used to treat type 2 diabetes and obesity. It works by helping the body secrete and use insulin better, inhibit glucagon release, slow stomach emptying, and reduce food intake by decreasing hunger signals. While it can be an effective treatment for diabetes and obesity, it can also cause side effects.


The most common side effects of semaglutide include nausea, vomiting, diarrhea, constipation, heartburn and abdominal pain. These side effects can be managed by drinking plenty of fluids and eating smaller, more frequent meals. It is also important to avoid high-fat foods the first 72 hours after the injection, as they can make the side effects worse. It is also recommended to limit acidic foods such as tomatoes, caffeine, alcohol, and citrus in order to avoid nausea and heartburn. Increasing raw vegetables and fiber can help with the constipation. Additionally, it is important to take semaglutide as prescribed and to not skip doses or double up on doses.


For the nausea, over the counter remedies such as Emetrol and Dramamine can he helpful. Remedies such as sniffing and alcohol wipe, carbonated beverages such as sprite or ginger ale, and ginger lozenges are also effective.


Other side effects of semaglutide include headaches, heart palpitations, muscle aches dizziness, and fatigue. To help manage these side effects, it is important to get plenty of rest, drink plenty of water, eat a balanced diet, and exercise regularly. If these symptoms persist, please see your medical provider right away, as it may be a sign of an electrolyte imbalance. Again, it is important to avoid alcohol, avoid nicotine, limit caffeine, and limit high sugar foods that can make the side effects worse.


By following these tips, you can help manage the side effects of semaglutide and continue to benefit from its effects. However, if you are still having trouble managing the side effects, it is important to talk to your doctor. They can help you find the best way to manage your side effects and make sure you are getting the most out of your treatment.


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